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2016 Nature

Evolution of Osteocrin as an activity-regulated factor in the primate brain.

Bulent Ataman*, Gabriella L Boulting*, Harmin DA, Yang MG, Baker-Salisbury M, Yap EL, Malik AN, Mei K, Rubin AA, Spiegel I, Durresi E, Sharma N, Hu LS, Pletikos M, Griffith EC, Partlow JN, Stevens CR, Adli M, Chahrour M, Sestan N, Walsh CA, Berezovskii VK, Livingstone MS, Greenberg ME

Nature. 2016 Nov 9;539(7628):242-247. doi: 10.1038/nature20111.  PMID: 27830782



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2016 Nature

Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons.

Alan R. Mardinly*, Ivo Spiegel*, A. Patrizi, E. Centofante, J. E. Bazinet, C. P. Tzeng, C. Mandel-Brehm, D. A. Harmin, H. Adesnik, M. Fagiolini & M. E. Greenberg

Nature. 2016, DOI: 10.1038/nature17187, PMID: 26958833


pdficon_large2015 Neuron

MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers.

Milena M. Andzelm*, Timothy J. Cherry*, David A. Harmin, Annabel C. Boeke, Charlotte Lee, Martin Hemberg, Basil Pawlyk, Athar N. Malik, Steven W. Flavell, Michael A. Sandberg, Elio Raviola and Michael E. Greenberg

Neuron 86, 247-263, doi:10.1016/j.neuron.2015.02.038 (2015).


pdficon_large2015 Nature

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome.

Harrison W. Gabel*, Benyam Kinde*, Hume Stroud, Caitlin S. Gilbert, David A. Harmin, Nathaniel R. Kastan, Martin Hemberg, Daniel H. Ebert and Michael E. Greenberg

Nature 522, 89-93, doi:10.1038/nature14319 (2015).


pdficon_large2015 PNAS

Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2.

Benyam Kinde*, Harrison W. Gabel*, Caitlin S. Gilbert, Eric C. Griffith, and Michael E. Greenberg

Proceedings of the National Academy of Sciences of the United States of America 112, 6800-6806, doi:10.1073/pnas.1411269112 (2015).


pdficon_large2015 PNAS

Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression.

Mandel-Brehm, C., Salogiannis, J., Dhamne, S. C., Rotenberg, A., and Greenberg, M. E

Proceedings of the National Academy of Sciences of the United States of America 112, 5129-5134, doi:10.1073/pnas.1504809112 (2015).


pdficon_large2014 Nature Neuroscience

Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.

Athar N. Malik*, Thomas Vierbuchen*, Martin Hemberg, Alex A. Rubin, Emi Ling, Cameron H. Couch, Hume Stroud, Ivo Spiegel, Kyle Kai-How Farh, David A. Harmin, and Michael E. Greenberg

Nature neuroscience 17, 1330-1339, doi:10.1038/nn.3808 (2014).


pdficon_large2014 Cell

Npas4 regulates excitatory-inhibitory balance within neural circuits through cell-type-specific gene programs.

Ivo Spiegel*, Alan R. Mardinly*, Harrison W. Gabel, Jeremy E. Bazinet, Cameron H. Couch, Christopher P. Tzeng, David A. Harmin, and Michael E. Greenberg

Cell 157, 1216-1229, doi:10.1016/j.cell.2014.03.058 (2014).


pdficon_large2013 Nature

The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.

Brenda L. Bloodgood*, Nikhil Sharma*, N., Browne, H. A., Trepman, A. Z., and Greenberg, M. E.

Nature 503, 121-125, doi:10.1038/nature12743 (2013).


pdficon_large2013 Nature

Activity-dependent neuronal signalling and autism spectrum disorder.

Ebert, D. H. and Greenberg, M. E.

Nature 493, 327-337, doi:10.1038/nature11860 (2013).


pdficon_large2013 Nature

Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR.

Daniel H. Ebert, Harrison W. Gabel, Nathaniel D.Robinson, Nathaniel R.Kastan, Linda S. Hu, Sonia Cohen, Adrija J.Navarro, Matthew J. Lyst, Robert Ekiert, Adrian P. Bird, and Michael E. Greenberg

Nature 499, 341-345, doi:10.1038/nature12348 (2013).


pdficon_large2012 Nature Neuroscience

A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.

Michael J Soskis*, Hsin-Yi Henry Ho*, Brenda L Bloodgood, Michael A Robichaux, Athar N Malik, Bulent Ataman, Alex A Rubin, Janine Zieg, Chao Zhang, Kevan M Shokat, Nikhil Sharma, Christopher W Cowan & Michael E Greenberg

Nature neuroscience. 2012, DOI: 10.1038/nn.3249, PMID: 23143520


2012 PNASpdficon_large

Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis.

Hsin-Yi Henry Ho*, Michael W. Susman*, Jay B. Bikoff, Yun Kyoung Ryu, Andrea M. Jonas, Linda Hu, Rejji Kuruvilla, and Michael Eldon Greenberg

Proceedings of the National Academy of Sciences of the United States of America 109, 4044-4051, doi:10.1073/pnas.1200421109 (2012).


pdficon_large2011 Neuron

The nogo receptor family restricts synapse number in the developing hippocampus.

Zachary P. Wills, Caleigh Mandel-Brehm, Alan R. Mardinly, Alejandra E. McCord, Roman J. Giger, and Michael E. Greenberg

Neuron 73, 466-481, doi:10.1016/j.neuron.2011.11.029 (2012).


pdficon_large2011 Neuron

Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function.

Sonia Cohen*, Harrison W. Gabel*, Martin Hemberg, Ashley N. Hutchinson, L. Amanda Sadacca, Daniel H. Ebert, David A. Harmin, Rachel S. Greenberg, Vanessa K. Verdine, Zhaolan Zhou, William C. Wetsel, Anne E. West, and Michael E. Greenberg

Neuron 72, 72-85, doi:10.1016/j.neuron.2011.08.022 (2011).


2011 Neuronpdficon_large

Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly.

Sarah E. Ross, Alejandra E. McCord, Cynthia Jung, Denize Atan, Stephanie I. Mok, Martin Hemberg, Tae-Kyung Kim, John Salogiannis, Linda Hu, Sonia Cohen, Yingxi Lin, Dana Harrar, Roderick R. McInnes, and Michael E. Greenberg

Neuron 73, 292-303, doi:10.1016/j.neuron.2011.09.035 (2012).


pdficon_large2011 CSH

Neuronal activity-regulated gene transcription in synapse development and cognitive function.

West, A. E. & Greenberg, M. E.

Cold Spring Harbor perspectives in biology 3, doi:10.1101/cshperspect.a005744 (2011).


pdficon_large2010 Neuron

Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice.

Sarah E. Ross, Alan R. Mardinly, Alejandra E. McCord, Jonathan Zurawski, Sonia Cohen, Cynthia Jung, Linda Hu,Stephanie I. Mok, Anar Shah, Erin M. Savner, Christos Tolias, Roman Corfas, Suzhen Chen, Perrine Inquimbert, Yi Xu, Roderick R. McInnes, Frank L. Rice, Gabriel Corfas, Qiufu Ma, Clifford J. Woolf,and Michael E. Greenberg

Neuron 65, 886-898, doi:10.1016/j.neuron.2010.02.025 (2010).


pdficon_large2010 Nature

Widespread transcription at neuronal activity-regulated enhancers.

Tae-Kyung Kim*, Martin Hemberg*, Jesse M. Gray*, Allen M. Costa, Daniel M. Bear, Jing Wu, David A. Harmin, Mike Laptewicz, Kellie Barbara-Haley, Scott Kuersten, Eirene Markenscoff-Papadimitriou, Dietmar Kuhl, Haruhiko Bito, Paul F. Worley, Gabriel Kreiman, and Michael E. Greenberg

Nature 465, 182-187, doi:10.1038/nature09033 (2010).


pdficon_large2010 Cell

The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.

Paul L. Greer, Rikinari Hanayama, Brenda L. Bloodgood, Alan R. Mardinly, David M. Lipton, Steven W. Flavell, Tae-Kyung Kim, Eric C. Griffith, Zachary Waldon, Rene Maehr, Hidde L. Ploegh, Shoaib Chowdhury, Paul F. Worley, Judith Steen, and Michael E. Greenberg

Cell 140, 704-716, doi:10.1016/j.cell.2010.01.026 (2010).


pdficon_large2010 Cell

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.

Seth S. Margolis*, John Salogiannis*, David M. Lipton, Caleigh Mandel-Brehm, Zachary P. Wills, Alan R. Mardinly, Linda Hu, Paul L. Greer, Jay B. Bikoff, Hsin-Yi Henry Ho, Michael J. Soskis, Mustafa Sahin, and Michael E. Greenberg

Cell 143, 442-455, doi:10.1016/j.cell.2010.09.038 (2010).


pdficon_large2008 Neuron

Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection.

Steven W. Flavell*, Tae-Kyung Kim*, Jesse M. Gray, David A. Harmin, Martin Hemberg, Elizabeth J. Hong, Eirene Markenscoff-Papadimitriou, Daniel M. Bear, and Michael E. Greenberg

Neuron 60, 1022-1038, doi:10.1016/j.neuron.2008.11.029 (2008).


pdficon_large2008 Neuron

Regulation of motor neuron specification by phosphorylation of neurogenin 2.

Yong-Chao Ma, Mi-Ryoung Song, Jin P. Park, Hsin-Yi Henry Ho, Linda Hu, Martin V. Kurtev, Janine Zieg, Qiufu Ma, Samuel L. Pfaff, and Michael E. Greenberg

Neuron 58, 65-77, doi:10.1016/j.neuron.2008.01.037 (2008).


pdficon_large2008 Nature

Activity-dependent regulation of inhibitory synapse development by Npas4.

Yingxi Lin, Brenda L. Bloodgood, Jessica L. Hauser, Ariya D. Lapan, Alex C. Koon, Tae-Kyung Kim, Linda S. Hu, Athar N. Malik, and Michael E. Greenberg

Nature 455, 1198-1204, doi:10.1038/nature07319 (2008).


pdficon_large2008 Neuron

A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition.

Elizabeth J. Hong, Alejandra E. McCord, and Michael E. Greenberg

Neuron 60, 610-624, doi:10.1016/j.neuron.2008.09.024 (2008).